Relationship of MTHFR gene polymorphisms with renal and cardiac disease

Table 5 Different prevalence of increased renal resistive index, abnormal left ventricular ejection fraction, normal left ventricular relaxation (E/A > 1), and left ventricular hypertrophy (normal renal function patients)

	Wild	Heterozygous	Heterozygous	Compound heterozygous	Homozygous	Homozygous	χ2	P
	MTHFR	C677T	A1298C	C677T and A1298C	A1298C	C677T
	(n = 58)	(n = 90)	(n = 56)	(n = 118)	(n = 62)	(n = 88)
high RRI	4	10	8	10	12	10	6.833	0.233
EF < 50%	0	0	0	2	0	0	5.798	0.326
E/A > 1	44	76	50	66	42	70	19.848	0.001
High LVMM	4	20	14	12	8	16	13.355	0.02

Pearson χ². MTHFR: Methylenetetrahydrofolate reductase; RRI: Renal resistive index; EF: Ejection fraction; LVMM: Left ventricular mass myocardial.