Relationship of MTHFR gene polymorphisms with renal and cardiac disease

Table 4 Different prevalence of increased renal resistive index, abnormal left ventricular ejection fraction, normal left ventricular relaxation (E/A > 1), and left ventricular hypertrophy (chronic renal failure patients-hemodialysis)

	Wild	Heterozygous	Heterozygous	Compound heterozygous	Homozygous	Homozygous	χ2	P
	MTHFR	C677T	A1298C	C677T and A1298C	A1298C	C677T
	(n = 36)	(n = 28)	(n = 20)	(n = 40)	(n = 20)	(n = 16)
High RRI	20	20	8	28	16	12	10.535	0.061
EF < 50%	4	4	4	12	4	0	9.114	0.105
E/A > 1	24	24	16	8	0	0	72.305	< 0.0001
High LVMM	8	16	4	32	5	4	38.428	< 0.0001

Pearson χ². MTHFR: Methylenetetrahydrofolate reductase; RRI: Renal resistive index; EF: Ejection fraction; LVMM: Left ventricular mass myocardial.