Relationship of MTHFR gene polymorphisms with renal and cardiac disease

Table 3 Different prevalence of increased renal resistive index, abnormal left ventricular ejection fraction, normal left ventricular relaxation (E/A > 1), and left ventricular hypertrophy (all patients)

	Wild	Heterozygous	Heterozygous	Compound heterozygous	Homozygous	Homozygous	χ2	P
	MTHFR	C677T	A1298C	C677T and A1298C	A1298C	C677T
	(n = 94)	(n = 118)	(n = 76)	(n = 154)	(n = 80)	(n = 104)
high RRI	24	30	16	38	28	22	5.746	0.332
EF < 50%	4	4	4	14	4	0	11.188	0.048
E/A > 1	68	100	66	74	42	70	53.497	< 0.0001
LVH (high LVMM)	12	36	18	44	13	20	14.923	0.011

Pearson χ². MTHFR: Methylenetetrahydrofolate reductase; RRI: Renal resistive index; EF: Ejection fraction; LVMM: Left ventricular mass myocardial; LVH: Left ventricular hypertrophy.