Relationship of MTHFR gene polymorphisms with renal and cardiac disease

Table 2 Characteristic of study population and differences between hemodialysis patients and no-hemodialysis n (%)

	Total	Dialysis patients	Patients with maintained	P
	(n = 630)	(n = 160)	Renal function
			(n = 470)
Women	336 (53.3)	72	264	0.0141
Obese patients	196 (31.1)	24	172	< 0.0001
Patients with GFR < 90	514 (81.6)	160	354	< 0.0001
NAFLD patients	256 (40.6)	28	228	< 0.0001
MTHFR group
Wild genotype	94 (14.9)	36	58	0.0161
MTHFR C677T	118 (18.7)	28	90
MTHFR 1298 AC	76 (12.1)	20	56
Compound heterozygous C677T and A1298C	158 (25.1)	40	118
MTHFR 1298 CC	80 (12.7)	20	60
MTHFR 677TT	104 (16.5)	16	88
Age, yr	54.60 ± 16.35	67.48 ± 14.57	50.22 ± 14.51	< 0.0001
BMI, kg/m2	27.70 ± 5.76	25.29 ± 3.97	28.52 ± 6.04	< 0.0001
Blood glucose, mg/dL	96.42 ± 26.42	95.33 ± 34.80	96.79 ± 22.91	0.545
Blood urea, mg/dL	52.47 ± 35.74	100.45 ± 41.07	36.13 ± 9.40	< 0.0001
Creatinin, mg/dL	2.36 ± 2.98	6.75 ± 2.99	0.86 ± 0.21	< 0.0001
GFR	62.46 ± 35.32	9.28 ± 3.60	80.56 ± 19.38	< 0.0001
Triglycerides, mg/dL	112.16 ± 64.71	131.90 ± 87.21	105.44 ± 53.48	< 0.0001
Total cholesterol, mg/dL	199.72 ± 44.43	175.80 ± 42.67	207.86 ± 42.05	< 0.0001
HDL cholesterol, mg/dL	54.81 ± 18.10	48.20 ± 15.63	57.07 ± 18.34	< 0.0001
LDL cholesterol, mg/dL	122.75 ± 39.63	101.22 ± 33.04	130.09 ± 39.05	< 0.0001
AST, U/L	21.81 ± 11.16	14.38 ± 4.07	24.34 ± 11.66	< 0.0001
ALT, U/L	16.54 ± 5.63	12.75 ± 4.15	17.83 ± 5.49	< 0.0001
γGT, U/L	33.10 ± 32.11	31.78 ± 19.18	33.55 ± 35.46	0.546
Insulin	11.84 ± 9.73	11.44 ± 10.77	11.98 ± 9.36	0.547
HOMA	3.02 ± 3.30	3.08 ± 3.94	3.00 ± 3.05	0.797
PTH, pg/mL	84.58 ± 105.79	162.38 ± 178.81	57.99 ± 36.85	< 0.0001
hsCRP, mg/dL	3.52 ± 7.01	2.62 ± 2.45	3.82 ± 7.98	0.107
Albumin, g/dL	4.60 ± 0.37	4.64 ± 0.35	4.58 ± 0.37	0.119
Albumin, %	62.39 ± 3.60	62.60 ± 3.03	62.31 ± 3.77	0.388
RRI	0.62 ± 0.06	0.68 ± 0.03	0.60 ± 0.06	< 0.0001
EF,%	65.93 ± 9.99	61.03 ± 12.62	67.87 ± 7.95	< 0.0001
E/A	1.14 ± 0.33	1.03 ± 0.39	1.18 ± 0.30	< 0.0001
LVMM/m2	104.95 ± 42.10	135.37 ± 55.56	93.84 ± 28.91	< 0.0001
AMDS	34.51 ± 3.09	35.93 ± 1.69	34.02 ± 3.31	< 0.0001
Homocysteine, μmol/L	2.1 ± 5.4	36.8 ± 8.5	21.2 ± 7.7	< 0.0001

¹Pearson χ². GFR: Glomerular filtration rate; BMI: Body mass index; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; γGT: γ-Glutamyl transpeptidase; hsCRP: High-sensitivity C-reactive protein; RRI: Renal resistive index; EF: Ejection fraction; LVMM: Left ventricular mass myocardial; AMDS: Adherence mediterranean diet score; MTHFR: Methylenetetrahydrofolate reductase; PTH: Parathyroid hormone; HOMA: Homoeostasis model-insulin resistance index; NAFLD: Non-alcoholic fatty liver disease.