Relationship of MTHFR gene polymorphisms with renal and cardiac disease

Table 1 Differences between methylenetetrahydrofolate reductase groups in all patients

	Wild genotype	Heterozygous MTHFR C677T	Heterozygous MTHFR 1298 AC	Compound heterozygous C677T and A1298C	Homozygous MTHFR 1298 CC	Homozygous MTHFR 677TT	P
	(n = 94)	(n = 118)	(n = 76)	(n = 154)	(n = 80)	(n = 104)
Age, yr	53.30 ± 11.89	51.59 ± 17.39	56.74 ± 16.55	57.91 ± 17.04	57.85 ± 14.70	50.12 ± 17.09	< 0.0001
BMI, kg/m2	27.26 ± 5.04	27.28 ± 5.95	28.04 ± 5.84	27.80 ± 6.13	27.01 ± 3.92	28.72 ± 6.61	0.316
GFR	48.84 ± 32.90	66.05 ± 36.70	64.16 ± 36.32	63.31 ± 38.35	61.57 ± 34.91	68.85 ± 27.33	0.002
Triglycerides, mg/dL	109.96 ± 75.73	113.21 ± 57.91	107.63 ± 42.67	128.72 ± 85.29	95.46 ± 37.07	103.94 ± 48.93	0.003
Total cholesterol, mg/dL	191.67 ± 41.71	206.29 ± 52.53	203.84 ± 38.73	198.28 ± 41.37	196.06 ± 54.99	201.54 ± 34.49	0.206
HDL cholesterol, mg/dL	58.11 ± 20.91	55.17 ± 15.75	55.28 ± 18.46	52.52 ± 18.49	52.51 ± 18.50	56.27 ± 16.35	0.175
LDL cholesterol, mg/dL	111.57 ± 34.89	128.47 ± 48.01	127.04 ± 31.67	120.81 ± 35.73	124.46 ± 48.10	124.89 ± 35.30	0.039
AST, U/L	19.50 ± 6.30	23.32 ± 14.23	27.93 ± 17.69	20.49 ± 6.91	21.76 ± 12.26	19.72 ± 5.99	< 0.0001
ALT, U/L	15.82 ± 4.59	16.46 ± 5.38	18.51 ± 5.75	16.46 ± 5.93	16.59 ± 5.74	15.92 ± 5.90	0.031
γGT, U/L	24.63 ± 12.20	33.82 ± 25.96	37.45 ± 38.03	42.71 ± 48.64	28.94 ± 15.17	25.37 ± 16.29	< 0.0001
HOMA	2.00 ± 1.13	3.18 ± 3.49	3.04 ± 2.27	4.04 ± 4.87	2.28 ± 1.07	2.76 ± 2.77	< 0.0001
PTH, pg/mL	84.94 ± 100.37	84.49 ± 170.97	78.37 ± 65.95	86.30 ± 76.75	86.53 ± 95.97	84.83 ± 81.83	0.997
hsCRP, mg/dL	2.58 ± 4.41	2.15 ± 2.79	6.30 ± 13.55	4.30 ± 8.66	3.99 ± 6.42	3.51 ± 4.95	< 0.001
RRI	0.60 ± 0.05	0.59 ± 0.05	0.59 ± 0.04	0.58 ± 0.05	0.59 ± 0.07	0.59 ± 0.06	0.392
EF, %	67.05 ± 8.18	66.94 ± 9.19	65.99 ± 9.15	63.52 ± 12.04	67.15 ± 11.63	66.51 ± 7.26	0.035
E/A	1.15 ± 0.36	1.20 ± 0.26	1.23 ± 0.34	1.09 ± 0.40	1.01 ± 0.26	1.18 ± 0.31	< 0.0001
LVMM/m2	100.48 ± 54.70	105.44 ± 33.79	107.69 ± 48.47	109.21 ± 41.02	110.38 ± 46.63	97.11 ± 28.69	0.179
AMDS	34.94 ± 2.52	34.97 ± 3.03	33.42 ± 3.88	34.23 ± 3.02	34.93 ± 2.68	34.46 ± 3.18	0.005
Homocysteine μmol/L	17.41 ± 3.00	25.53 ± 8.12	28.58 ± 9.23	18.68 ± 9.01	21.26 ± 9.17	18.83 ± 6.25	< 0.0001

BMI: Body mass index; GFR: Glomerular filtration rate; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; γGT: γ-Glutamyl Transpeptidase; hsCRP: High-sensitivity C-reactive protein; RRI: Renal resistive index; EF: Ejection fraction; LVMM: Left ventricular mass myocardial; AMDS: Adherence mediterranean diet score; MTHFR: Methylenetetrahydrofolate reductase; PTH: Parathyroid hormone; HOMA: Homoeostasis model-insulin resistance index.