Metabolic syndrome and chronic kidney disease: Current status and future directions

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Nov 6, 2014 (publication date) through Nov 24, 2024

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World Journal of Nephrology

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2220-6124

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Nephrol. Nov 6, 2014; 3(4): 210-219
Published online Nov 6, 2014. doi: 10.5527/wjn.v3.i4.210

Table 3 Potential mechanisms of chronic kidney disease in metabolic syndrome

Mechanism	Ref.
Oxidative stress	[34,40]
Increased pro-inflammatory cytokines (leptin, interleukin 6, tumor necrosis factor α)	[36]
Increased connective tissue growth and/or fibrosis factors (connective tissue growth factor, transforming growth factor β, type IV collagen)	[35,37-39]
Increased glomerular volume and podocyte hypertrophy	[44]
Triglyceride- and free-fatty acid induced injury	45
Increased ischemia and microvascular injury (angiotensin II)	[46,47]
Hyperuricemia	[48,49]

Citation: Prasad GVR. Metabolic syndrome and chronic kidney disease: Current status and future directions. World J Nephrol 2014; 3(4): 210-219
URL: https://www.wjgnet.com/2220-6124/full/v3/i4/210.htm
DOI: https://dx.doi.org/10.5527/wjn.v3.i4.210