Therapeutic target for nephrotic syndrome: Identification of novel slit diaphragm associated molecules

Table 1 Summary of the critical slit diaphragm and the novel slit diaphragm associated molecules

Ref.	Molecules	Predicted molecule weight	Functions in the slit diaphragm
Schnabe et al[26]	ZO-1	225 kDa	Interact with NEPH1
Kestilä et al[3]	Nephrin	180 kDa	Maintaining the barrier function
Schwarz et al[34]	Podocin	42 kDa	A raft-associated component and interact with nephrin and CD2AP
Shih et al[6]	CD2AP	80 kDa	Interact with nephrin and anchor nephrin to the cytoskeleton
Liu et al[37]	NEPH1	110 kDa	Interact with ZO-1 and nephrin
Winn et al[9], Reiser et al[10]	TRPC6	About 110 kDa	Interact with nephrin and podocin
Miyauchi et al[45]	SV2B	80 kDa	The proper arrangement of CD2AP
Hashimoto et al[46]	Ephrin-B1	50 kDa	Maintaining the slit diaphragm structure
Saito et al[47]	Neurexin	150 kDa	Regulating the slit diaphragm function

ZO-1: Zonula occludens-1; CD2AP: CD2 associated protein; TRPC6: Transient receptor potential-6.