Silent diabetic nephropathy

Table 3 Clinical and histopathological findings according to glomerular classification of diabetic nephropathy n (%)

		I-IIa-IIb (n = 18)	III (n = 23)	IV (n = 4)
Age (yr)		59.9 ± 12.2	58.1 ± 14.1	52.3 ± 15.4
Years of diabetes		9.1 ± 7.4	9.3 ± 6.3	15.1 ± 18
BMI (kg/m2)		29 ± 4.9	30.1 ± 6	26.8 ± 2.4
Serum creatinine (mg/dL)		2 ± 1.2	2.2 ± 1.4	4.4 ± 1.9
eGFR (mL/min per 1.73 m2)		42.3 ± 21.9	40.4 ± 22.9	17.6 ± 12.3
HbA1c (%)		6.7 ± 1.4	6.3 ± 1.3	6.7 ± 2
Proteinuria (g/d)		3.1 ± 2.6	5.2 ± 4	4.7 ± 5.6
Serum albumin (g/dL)		3.6 ± 0.7	3.3 ± 0.7	2.9 ± 0.7
Serum cholesterol (mg/dL)		165.4 ± 71.6	191.5 ± 34.6	213 ± 0
Hypertension		16 (88.9)	22 (95.7)	4 (100)
Diabetic retinopathy		7 (38.9)	9 (39.1)	2 (50)
CVD		7 (38.9)	6 (26.1)	3 (75)
RPKI		0	6 (33.3)	7 (30.4)
Patients with renal events		9 (50)	15 (65.2)	4 (100)
RRT		6 (33.3)	11 (47.8)	4 (100)
1Years from biopsy to renal event		4.2 ± 1.2	3.4 ± 1.4	0.4 ± 0.4
% of global glomerulosclerosis		18.1 ± 12.8	18.4 ± 15.1	77.3 ± 16.9
Interstitial fibrosis	0	1 (5.6)	0	0
and tubular atrophy	1	10 (55.6)	13 (56.5)	0
	2	5 (27.8)	9 (39.1)	1 (25)
	3	2 (11.1)	1 (4.3)	3 (75)
Interstitial inflammation	0	3 (16.7)	0	0
	1	14 (77.8)	22 (95.7)	4 (100)
	2	1 (5.6)	1 (4.3)	0
Arteriolar hyalinosis	0	1 (5.6)	1 (4.3)	1 (25)
	1	3 (16.7)	2 (8.7)	0
	2	14 (77.8)	20 (87)	3 (75)
Large vessel arteriosclerosis (yes)		17 (94.4)	19 (86.4)	4 (100)

¹Years from biopsy to renal event are expressed as medians ± SEs, estimated by Kaplan-Meier method. CVD: Cardiovascular disease; BMI: Body mass index; RPKI: Rapidly progressive kidney injury; RRT: Renal replacement therapy; eGFR: Estimated glomerular filtration rate.