Vitamin E and diabetic nephropathy in mice model and humans

Figure 6 Increased renal iron deposition in the proximal tubule of haptoglobin 2-2 diabetes mellitus mice. Perl’s iron stain was used to localize iron in paraffin-embedded kidney sections in haptoglobin (Hp) 1-1 and Hp 2-2 mice with and without diabetes mellitus (DM). Arrow indicates iron-induced stain in blue (× 400 magnification) located within proximal tubular cells. There was a significant increase in iron staining in the renal tissue of Hp 2-2 DM (D) vs Hp 1-1 DM (D) and Hp 2-2 non-DM mice (P < 0.001).