Vitamin E and diabetic nephropathy in mice model and humans

Figure 4 Total glomerular and glomerular tuft area is increased in haptoglobin 2-2 diabetes mellitus mice. Periodic acid-Schiff stained, paraffin-embedded sections from kidneys of haptoglobin (Hp) 1-1 and Hp 2-2 mice with D or without diabetes mellitus (DM). Areas were measured using Image Pro software. Values are expressed as mean ± SE (30 glomeruli measured for each animal). There was a significant increase in total glomerular area in Hp 2-2 DM mice vs Hp 1-1 DM mice (P < 0.001) as well as between Hp 2-2 DM and Hp 2-2 non-DM mice (P < 0.001). There was a significant decrease in total glomerular area in Hp 2-2 DM mice with vitamin E (Vit-E; P < 0.05).