Inflammatory status in chronic renal failure: The role of homocysteinemia and pro-inflammatory cytokines

Table 2 Inflammation markers, total homocysteine and cytokines in chronic renal failure patients

	CRF 1	CRF 2	CRF 3	CRF 4	HD	PD	P
TNF-α (pg/mL)	0.39 ± 0.03	3.81 ± 1.52	7.80 ± 2.76	10.04 ± 1.61	16.38 ± 5.52	14.04 ± 3.40	0.001
IL-1β (pg/mL)	3.24 ± 0.10	3.57 ± 0.47	6.69 ± 1.02	7.76 ± 0.66	9.63 ± 3.50	6.51 ± 1.37	0.001
IL-6 (pg/mL)	8.20 ± 0.22	8.79 ± 1.04	8.88 ± 0.71	9.66 ± 0.56	11.05 ± 3.59	10.15 ± 1.66	0.001
tHcy (μmol/L)	8.05 ± 2.43	11.95 ± 5.26	20.16 ± 2.62	25.34 ± 3.93	32.27 ± 12.08	28.37 ± 4.98	0.001
CRP (mg/L)	3.29 ± 2.33	5.54 ± 2.16	8.18 ± 3.33	13.5 ± 4.28	18.17 ± 6.38	17.97 ± 4.85	0.001
Fib (g/L)	3.58 ± 0.82	4.51 ± 0.47	5.80 ± 1.21	6.05 ± 0.57	6.86 ± 1.06	5.91 ± 0.59	0.001
Ferritin (ng/mL)	47.66 ± 25.24	51.12 ± 34.57	74.22 ± 43.18	83.83 ± 44.99	169.90 ± 62.16	90.08 ± 22.09	0.001
Transferrin (g/L)	2.73 ± 0.47	2.41 ± 0.23	2.29 ± 0.37	2.03 ± 0.49	1.86 ± 0.39	1.78 ± 0.21	0.001

Data are presented as the mean ± SD. Statistically significant differences between all the groups (P < 0.001). TNF-α: Tumor necrosis factor-α; IL-1β: Interleukin-1β; IL-6: Interleukin-6; tHcy: Total homocysteine; CRP: C-reactive protein; Fib: Fibrinogen; HD: Hemodialysis; PD: Peritoneal dialysis.