Uric acid and chronic kidney disease: A time to act?

Table 3 Studies investigating the association between serum uric acid and renal function/graft survival in patients with kidney transplantation

Ref.	Numerosity	Major findings
Gerhardt et al[48]	375	Hyperuricemia (> 8.0 mg/dL in men and > 6.2 mg/dL in women), associated with reduced graft survival
Armstrong et al[49]	90	UA independent predictor of follow-up e-GFR, but not of e-GFR change over time
Akgul et al[50]	133	No association found between serum UA and the development of chronic allograft nephropathy
Saglam et al[51]	34	Serum UA associated to development of cyclosporine A nephropathy (biopsy proven)
Akalin et al[52]	307	Hyperuricemia 6 mo after transplantation significantly associated with new cardiovascular events and graft dysfunction
Bandukwala et al[53]	405	Hyperuricemia associated with cardiovascular events, and, inversely with e-GFR
Karbowska et al[54]	78	Hyperuricemia associated with markers of endothelial dysfunction and inflammation
Meier-Kriesche et al[55]	1645	UA levels one month after transplantation not associated with follow-up e-GFR, after adjustment for baseline renal function
Haririan et al[56]	212	Serum UA during the first six months postransplant, is an independent predictor of graft survival
Boratyńska et al[57]	100	Serum UA not associated to graft survival during 30 mo of follow-up
Kim et al[58]	556	Serum UA levels affect graft function, even after adjustment for baseline e-GFR
Wang et al[59]	524	Retrospective study: UA significantly lower in patients with longer graft survival

e-GFR: Estimated glomerular filtration rate; UA: Uric acid.