Pericytes synthesize renin

Figure 2 Immunostaining for renin (brown) in wild type (A-D) and angiotensinogen deficient mice (E-H) during postnatal life (P1, P5, P10 and P45) Higher magnification. A: Renin expression in a transversal section of an arteriole and in isolated pericytes (arrowheads); B: Renin expression in a transversal section of a branching arteriole and in isolated pericytes (arrowheads); C: Renin expression is still present in arterioles beyond the juxtaglomerular areas (JGAs) and in isolated pericytes (arrowheads); D: Renin expression is restricted to the JGAs; E: Renin expression in arterioles and isolated pericytes (arrowheads) similar to A; F: Renin expression in an arteriole beyond the JGA similar to B but with a clear increase in the density of pericytes expressing renin (some marked with arrowheads); G: Peritubular pericytes (some marked with arrowheads) show a marked increase in renin expression; H: Renin expression in enlarged arterioles and in peritubular pericytes (arrowheads). WT: Wild type; AGT: Angiotensinogen deficient. Bars: 50 μm.