Longitudinal assessment of measured and estimated glomerular filtration-rate in autosomal dominant polycystic kidney disease: Real practice experience

Table 3 Measured and estimated month-6 glomerular filtration rates changes versus baseline in the overall study autosomal-dominant polycystic kidney disease patients (n = 37) and ranked according to measured glomerular filtration rate ≤ 80 (n = 17) and > 80 (n = 20) mL/minute

		Glomerular filtration rate (mL/minute)
		Overall (n = 37)	mGFR ≤ 80 (n = 17)	mGFR > 80 (n = 20)
Iohexol	Baseline (mean ± SD)	85.6 ± 24.6	65.6 ± 10.2	102.7 ± 19.8
	Month-6 (mean ± SD)	81.2 ± 26.2	63.2 ± 16.1	96.6 ± 16.3
	Difference
	mean ± SD	-4.4 ± 10.3	-2.4 ± 9.5	-6.1 ± 10.8
	95%CI	-7.8 to -1.0	-7.2 to 2.5	-11.2 to -1.1
	P value	0.0132a	0.2842b	0.0136b
Chronic kidney disease epidemiology collaboration	Baseline (mean ± SD)	81.3 ± 23.7	71.2 ± 20.8	89.9 ± 23.0
	Month-6 (mean ± SD)	79.0 ± 23.9	69.1 ± 24.2	87.5 ± 20.6
	Difference
	mean ± SD	-2.3 ± 12.7	-2.2 ± 15.2	-2.4 ± 10.4
	95%CI	-6.5 to 2.0	-10.0 to 5.7	-7.3 to 2.5
	P value	0.2824a	0.4691b	0.4939b
Modification of diet in renal disease	Baseline (mean ± SD)	71.7 ± 18.9	63.6 ± 17.6	78.2 ± 17.7
	Month-6 (mean ± SD)	71.2 ± 19.2	63.5 ± 18.6	77.4 ± 17.7
	Difference
	mean ± SD	-0.5 ± 9.3	-0.1 ± 11.9	-0.8 ± 6.9
	95%CI	-3.6 to 2.7	-6.4 to 6.2	-4.0 to 2.3
	P value	0.7560a	0.7119b	0.5196b
Creatinine clearancec	Baseline (mean ± SD)	100.6 ± 34.1	74.0 ± 15.4	127.3 ± 27.4
	Month-6 (mean ± SD)	98.2 ± 34.0	77.6 ± 19.2	118.9 ± 33.5
	Difference
	mean ± SD	-2.4 ± 24.5	3.6 ± 10.3	-8.4 ± 32.7
	95%CI	-12.7 to 8.0	-2.9 to 10.1	-29.2 to 12.4
	P value	0.7642b	0.3668b	0.4697b

^aPaired samples t student test.

^bWilcoxon test.

^cMonth-6 measurements available in 24 patients in the overall study sample, 12 in the measured glomerular filtration rate (mGFR) ≤ 80 and in the mGFR > 80 groups, respectively.

mGFR: Measured glomerular filtration rate.