Clinical course and outcome of adult patients with primary focal segmental glomerulosclerosis with kidney function loss on presentation

Table 4 Comparison of main clinicopathological parameters and outcomes among the two groups [those with kidney function loss (n = 81) and those with normal kidney function (n = 254) at presentation] of adult focal segmental glomerulosclerosis patients treated with steroids

Parameters	Kidney function loss, n = 81	Normal kidney function, n = 254	P value
Age in years	36.3 ± 14.7	26.5 ± 10.4	< 0.001
Sex as male:female	2.5:1	1.9:1	0.328
Systolic in mmHg	131.9 ± 19.8	128.4 ± 17.9	1.464
Diastolic in mmHg	86.5 ± 12.8	83.9 ± 12.2	1.664
Serum albumin in g/dL	1.9 ± 1.0	1.9 ± 1.1	0.807
Initial proteinuria in mg/24 hours	5626.2 ± 3787	4396.0 ± 2805.2	0.009
Serum creatinine in mg/dL	2.2 ± 1.3	0.8 ± 0.2	< 0.001
Follow-up duration in weeks	136.8 ± 120.6	152.94 ± 115.6	0.243
Total steroid dose in mg	4391.5 ± 1502.3	4279.6 ± 2039.5	0.649
Duration of steroid treatment in weeks	19.90 ± 14.4	23.27 ± 23.9	0.231
Time to remission	11.3 ± 6.7	12.6 ± 20.4	0.705
Number of glomeruli with global sclerosis	3.6 ± 2.9	2.0 ± 1.5	< 0.001
Number of glomeruli with segmental sclerosis	3.2 ± 3.2	2.9 ± 2.6	0.61
Tubular atrophy
Mild	39 (79.6)	133 (90.5)	0.044
Moderate	10 (20.4)	14 (9.5)
Outcomes
Complete remission	20/81 (24.7)	66/254 (25.9)	0.428
Partial remission	9/81 (11.1)	42/254 (16.5)
No remission	52/81 (64.2)	146/254 (57.4)
Doubling of serum creatinine	13/52 (25.0)	16/146 (10.9)	0.007

Data are n (%).