What is new in the pathogenesis and treatment of IgA glomerulonephritis

Table 2 The association between genetic wide association studies and new candidate genes

Ref.	Published date	Ancestry	GWAS population	Genome-wide significant loci (candidate gene)
Susceptibility to IgA nephropathy
Feehally et al[12]	2010	European ancestry	244 cases and 4980 healthy controls	6p21 (HLA)
Gharavi et al[4]	2011	Chinese and European ancestry	3144 cases and 2822 healthy controls	6p21 (HL-DQB1/DRB1; PSMB9/TAPI; HLA-DPA1/DPB2), 1q32 (CFHR3/R1), 22q12 (HORMAD2)
Yu et al[13]	2011	Chinese ancestry	1434 cases and 4270 healthy controls	6p21 (HLA), 8p23 (DEFAs), 17p13 (TNFSF13), 22q12 (MTMR3)
Kiryluk et al[14]	2014	European and East Asian ancestry	7658 cases and 12954 healthy controls	6p21 (HLA-DQ-HLA-DR; TAP1-PSMB8; HLA-DP), 1p13 (VAV3), 1q32 (CFHR3-CFHR1 deletion), 8p23 (DEFAs), 9q34 (CARD9), 16p11 (ITGAM-ITGAX), 17p13 (TNFSF13), 22q12 (HORMAD2)
Li et al[15]	2015	Chinese ancestry	1434 cases and 10661 healthy controls	6p21 (HLA), 3q27 (ST6GAL1), 8p23 (DEFA), 8q22 (ODF1-KLF10), 11p11 (ACCS), 16p11 (ITGAX-ITGAM, 22q12 (HORMAD2)
Jeong et al[16]	2019	Korean ancestry	188 cases and 455 healthy controls	10p15 (ANKRD16)
Li et al[17]	2020	Chinese and European ancestry	2628 cases and 11563 healthy controls	6p21 (HLA), 1q23 (FCRL3), 1p36 (PAD14), 6p25 (DUSP22/IRF4), 8p23 (DEFA), 16p11 (ITGAX-ITGAM), 17p13 (TNPSF12-TNPSF13), 22q12 (MTMR3/HORMAD2)
Zhou et al[18]	2021	Chinese ancestry	601 cases and 4076 healthy controls	6p21 (GABBR1), suggestive genes (TGFB1, CCR6, STAT3, CFB)
Li et al[19]	2023	Chinese ancestry	2378 cases and 15642 healthy controls	6p21 (HLA), 6p21.1 (VEGFA), 16q22.2 (PKD1 L3), 17p13 (TNFSF13)
Kiryluk et al[20]	2023	European and East Asian ancestry	10146 cases and 28751 healthy controls	6p21 (HLA), 8 known non-HLA loci (CFH, FCRL3, IRF4/DUSP22, DEFA ¼, CARD9, ITGAM/ITGAX, TNFSF 13/12, MTMR3/HORMAD2/LIF/OSM), 16 new non HLA loci (TNFSF4/18, CD28, REL, PF4V1, LY86, LYN, ANXA13, TNFSF8/15, ZMIZ1, REEP3, OVOL1/RELA, ETS1, IGH, IRF8, TnFRSF13B, and FCAR) CCR6 (only in the East Asian cohorts)
Serum Gd-IgA1 levels
Gale et al[21]	2017	European and Chinese ancestry	513 subsets	7p21 (C1GALT1)
Kiryluk et al[22]	2017	European and East Asian ancestry	2633 subsets	7p21 (C1GALT1), Xq24 (C1GALT1C1)
Wang et al[23]	2021	Chinese ancestry	1127 patients with IgAN	7p22 (C1GALT1), 9q22 (GALNT12)