Clinicopathological features and medium-term outcomes of histologic variants of primary focal segmental glomerulosclerosis in adults: A retrospective study

Figure 1 Histological features of common variants of focal segmental glomerulosclerosis. A: Medium-power view showing three glomeruli with segmental scars in indeterminate locations in a case of focal segmental glomerulosclerosis (FSGS), not otherwise specified. Mild patchy tubular atrophy and interstitial scarring is seen in the background [Periodic Acid-Schiff (PAS), × 200]; B: High-power view showing one glomerulus with segmental scar and adhesion formation involving the tip domain diagonally opposite the vascular pole, an example of the TIP variant (PAS, × 400); C: High-power view showing one glomerulus with segmental collapse of capillary tufts accompanied by podocyte hypertrophy and hyperplasia in a case of collapsing FSGS. Many proteinaceous droplets are also seen in the cytoplasm of podocytes (Jone’s methenamine silver, × 400).