Heterogeneity in cardiorenal protection by Sodium glucose cotransporter 2 inhibitors in heart failure across the ejection fraction strata: Systematic review and meta-analysis

Figure 5 Meta-analysis of Sodium glucose cotransporter 2 inhibitors’ effect on ‘cardiovascular death or heart failure hospitalizations or urgent visits’ across the patients’ baseline left ventricular ejection fraction strata. A: Left ventricular ejection fraction (LVEF) < 30% vs ≥ 30%; B: LVEF < 40% vs ≥ 40%; C: LVEF < 45% vs LVEF ≥ 45%; D: LVEF < 50% vs LVEF ≥ 50%; E: LVEF < 60% vs LVEF ≥ 60%. ^aper 1000 person-years; ^bper 100 person-years; ^canalysis based on the “history of previous LVEF < 40%” reported by DELIVER trial; LVEF: Left ventricular ejection fraction; N/A: Not available.