Effectiveness and safety of apixaban and rivaroxaban vs warfarin in patients with atrial fibrillation and chronic kidney disease

Table 2 Sensitivity analysis of negative controls after inverse probability of treatment weighting in an on-treatment analysis

	Incident rate of rivaroxaban 15 mg 100 PY (95%CI)	Incident rate of warfarin 100 PY (95%CI)	HR (95%CI)1	P value
Diabetes complications	1.1 (0.2-2.0)	1.1 (0.6-1.5)	1.02 (0.40-2.60)	0.96
	Incident rate of rivaroxaban 20 mg 100 PY (95%CI)	Incident rate of warfarin 100 PY (95%CI)	HR (95%CI)1	P value
Diabetes complications	1.5 (0.6-2.4)	1.0 (0.6-1.5)	1.48 (0.72-3.06)	0.29
	Incident rate of apixaban 2.5 mg 100 PY (95%CI)	Incident rate of warfarin 100 PY (95%CI)	HR (95%CI)1	P value
Diabetes complications	0.8 (0.3-1.3)	1.2 (0.8-1.7)	0.66 (0.31-1.41)	0.28
	Incident rate of apixaban 5.0 mg 100 PY (95%CI)	Incident rate of warfarin 100 PY (95%CI)	HR (95%CI)	P value
Diabetes complications	0.7 (0.2-1.1)	1.4 (0.9-1.9)	0.49 (0.24-1.02)	0.06

A significant value is for P < 0.05 vs warfarin.

¹For the negative control, we assessed the risk of diabetic complications (ICD-9: 250.1-250.9, 357.2, and 366.41; ICD-10: E10-E14 excluding E10.9, E11.9, E12.9, E13.0, and E14.9).

CI: Confidence interval; HR: Hazard ratio; PY: Person-years.