New antigens involved in membranous nephropathy beyond phospholipase A2 receptor

Table 3 Demographic and clinical characteristics according to antigen

Total 270	PLA2R 220	EXT1/EXT2 11	NELL 1 6	PCDH7 3	THSD7A 1	NCAM-1 1	Septule negative 28
Age	54.0 (43.2-61.0)	40.0 (25.0-48.0)	57.0 (36.7-66.5)	73 (69.0-74.0)	67.0	46	52 (44.5-66.5)
Male sex % (n)	75.0 (165/220)	27.2 (3/11)	66.6 (4/6)	33.3 (1/3)	100 (1/1)	0 (0/1)	60.7 (17/28)
Serum creatinine (mg/dL)	1.1 (0.9-1.4)	1.0 (0.7-1.1)	1.9 (1.0-4.9)	1.1 (1.03-1.48)	0.9	0.6	1.2 (0.9-1.7)
eGFR (mL/min/1.73 m2)	68 (49.9-91.0)	85.0 (65.2- 113.4)	38.3 (14.5-75.7)	57 (39.8-66.6)	89.5	114.0	67 (40.0-95.0)
Proteinuria (g/24 h)	8.0 (5.2-12.0)	5.6 2.6-9.3)	11.0 (6.8-16.1)	3.2 ( 1.55-6.05)	14.4	5.7	4.5 (3.2-9.9)
Malignancy %	5.0 (11/220)	9.0 (1/11)	33.3 (2/6)	-	100 (1/1)	-	25.0 (7/28)
Autoimmunity %	5.4 (12/220)	81.8 (9/11)	33.3 (2/6)	-	-	-	46.4 (13/28)
Paraproteinmemia %	4.0 (9/220)	-	-	-	100 (1/1)	-	35 (1/28)
Infection %	0.4 (1/220)	-	-	-	-	-	-
NSAID %	1.8 (4/220)	-	16.6 (1/6)	-	-	-	14.2 (6/28)
No associated disease %	84.0 (185/220)	18.1 (2/11)	16.6 (1/6)	100 (3/3)	-	100 (1/1)	21.4 (6/28)

eGFR: Estimated glomerular filtration rate; EXT: Exostosin; NCAM-1: Neural cell adhesion molecule 1; NELL-1: Neural epidermal growth factor-like 1 protein; NSAID: Nonsteroidal anti-inflammatory drug; PCDH7: Protocadherin; PLA2R: Phospholipase A2 receptor; THSD7A: Thrombospondin type 1 domain containing 7A.