Real-world cure rates for hepatitis C virus treatments that include simeprevir and/or sofosbuvir are comparable to clinical trial results

doi:10.5501/wjv.v6.i4.59

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World Journal of Virology

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Virol. Nov 12, 2017; 6(4): 59-72
Published online Nov 12, 2017. doi: 10.5501/wjv.v6.i4.59

Table 4 Cost of care and cost-per-sustained virological response by treatment for 508 patients in study

	HCV medications ($)	Adverse Event costs ($)	Lab fees ($)	Provider fees ($)	Total cost of care ($)	¹SVR12 rate (%)	Cost-per-SVR ($)
SMV/SOF ± RBV	26379909	65231	89947	154488	26689574	153/178 (86)	174442 (18588)
SOF/RBV genotype	31616725	143770	136353	215584	32112432	144/234 (62)	223003 (77946)
1	15723055	106274	59942	94435	15983705	45/102 (44)	355193 (98493)
2	5736955	32477	37540	61136	5868109	57/69 (83)	102949 (21346)
3	8279942	5019	31914	49381	8366257	35/52 (67)	239036 (48831)
4	1876773		6956	10633	1894362	7/11 (64)	270623 (124)
SOF/PEG/RBV	9275858	80370	48929	82045	9487202	75/96 (78)	126469 (31052)

¹SVR12 rate was calculated with imputations for 14 patients with an EOT response based on the average SVR12 rate for other patients on the same regimen. SMV: Simeprevir; SOF: Sofosbuvir; RBV: Ribavirin; PEG: Pegylated interferon; SVR: Sustained virological response; HCV: Hepatitis C virus.

Citation: Bichoupan K, Tandon N, Crismale JF, Hartman J, Del Bello D, Patel N, Chekuri S, Harty A, Ng M, Sigel KM, Bansal MB, Grewal P, Chang CY, Leong J, Im GY, Liu LU, Odin JA, Bach N, Friedman SL, Schiano TD, Perumalswami PV, Dieterich DT, Branch AD. Real-world cure rates for hepatitis C virus treatments that include simeprevir and/or sofosbuvir are comparable to clinical trial results. World J Virol 2017; 6(4): 59-72
URL: https://www.wjgnet.com/2220-3249/full/v6/i4/59.htm
DOI: https://dx.doi.org/10.5501/wjv.v6.i4.59