Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients

Table 5 Correlations among metalloproteases, their tissue inhibitors and liver fibrosis parameters

	MMP-3	MMP-8	MMP-9	MMP-10	TIMP-1	TIMP-2	TIMP-4	TE	YFPI	APRI	Forns	FIB-4
MMP-2	0.19 (0.04)	0.21 (0.02)	0.21 (0.02)	0.20 (0.09)	0.29 (0.002)	0.29 (0.002)	0.35 (0.0002)	0.23 (0.016)	0.30 (0.058)	0.20 (0.03)	0.19 (0.04)	0.20 (0.03)
MMP-3		0.29 (0.0006)	0.30 (0.0006)	0.15 (0.19)	0.33 (0.0001)	0.27 (0.002)	0.38 (< 0.0001)	0.09 (0.3)	0.001 (0.99)	0.16 (0.06)	0.16 (0.06)	0.10 (0.24)
MMP-8			0.69 (< 0.0001)	0.25 (0.02)	0.71 (< 0.0001)	0.40 (< 0.0001)	0.24 (0.005)	-0.02 (0.8)	-0.15 (0.3)	-0.01 (0.9)	0.03 (0.8)	-0.03 (0.7)
MMP-9				0.21 (0.06)	0.71 (< 0.0001)	0.16 (0.06)	0.21 (0.01)	-0.21 (0.01)	-0.32 (0.02)	-0.17 (0.047)	-0.11 (0.2)	-0.20 (0.02)
MMP-10					0.12 (0.3)	0.22 (0.051)	0.11 (0.3)	0.01 (0.9)	-0.09 (0.7)	0.12 (0.3)	-0.08 (0.5)	-0.03 (0.8)
TIMP-1						0.40 (< 0.0001)	0.39 (< 0.0001)	0.02 (0.8)	-0.04 (0.8)	-0.02 (0.8)	0.07 (0.4)	0.01 (0.9)
TIMP-2							0.33 (0.0001)	0.28 (0.0009)	0.25 (0.08)	0.35 (< 0.0001)	0.20 (0.018)	0.36 (< 0.0001)
TIMP-4								0.11 (0.2)	0.03 (0.8)	0.14 (0.12)	0.06 (0.5)	0.19 (0.03)
TE									0.94 (< 0.0001)	0.75 (< 0.0001)	0.59 (< 0.0001)	0.82 (< 0.0001)
YFPI										0.63 (< 0.0001)	0.51 (0.0001)	0.74 (< 0.0001)
APRI											0.55 (< 0.0001)	0.90 (< 0.0001)
Forns												0.67 (< 0.0001)

Values are expressed as r (P value). MMP: Matrix metalloprotease; HCV: Hepatitis C virus; TE: Transient elastometry; YFPI: Yearly fibrosis progression index (only for HCV-infected patients); TIMP: Tissue inhibitor of metalloprotease.