Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients

Table 4 Metalloproteases and their tissue inhibitors according to the single nucleotide polymorphisms genotypes

SNP	Genotype	MMP-2	MMP-3	MMP-8	MMP-9	MMP-10	TIMP-1	TIMP-2	TIMP-4
MMP-1 -16071G/2G	1G1G	0.379 (0.195-0.736)	16.69 (11.00-25.33)	0.035 (0.013-0.095)	19.93 (11.59-34.28)	1.782 (0.350-9.071)	41.73 (30.87-56.42)	6.79 (4.52-10.21)	0.031 (0.010-0.091)
	1G2G	0.803 (0.409-1.575)	19.87 (15.13-26.10)	0.041 (0.012-0.134)	22.35 (13.37-37.36)	1.451 (0.417-5.047)	54.07 (39.44-74.14)	7.30 (4.49-11.87)	0.047 (0.020-0.113)
	2G2G	0.609 (0.449-0.826)	14.72 (11.57-18.73)	0.027 (0.017-0.042)	23.65 (17.07-32.76)	3.345 (1.512-7.399)	50.34 (42.16-60.10)	8.39 (6.54-10.76)	0.032 (0.019-0.053)
	P value	0.18	0.4	0.7	0.9	0.5	0.4	0.6	0.7
MMP-8 799C/T	CC	0.655 (0.473-0.908)	15.96 (12.94-19.68)	0.048 (0.025-0.090)	29.93 (19.94-44.94)	4.650 (1.354-15.97)	61.60 (49.94-75.99)	11.67 (8.59-15.85)	0.041 (0.023-0.073)
	CT	0.568 (0.409-0.787)	13.05 (10.22-16.65)	0.031 (0.018-0.054)	21.30 (15.50-29.28)	2.179 (1.201-3.953)	47.17 (38.80-57.34)	6.71 (5.50-8.18)	0.035 (0.021-0.058)
	TT	0.432 (0.280-0.668)	16.66 (13.35-20.81)	0.020 (0.015-0.027)	18.86 (14.03-25.37)	1.623 (0.938-2.808)	47.75 (40.75-55.94)	8.12 (5.89-11.20)	0.050 (0.030-0.084)
	P value	0.3	0.3	0.09	0.17	0.17	0.11	0.01	0.6
MMP-9 1562 C/T	CC	0.495 (0.385-0.637)	15.42 (13.11-18.14)	0.034 (0.024-0.049)	22.39 (17.79-28.19)	2.405 (1.462-3.957)	52.23 (46.17-59.07)	8.39 (7.18-9.80)	0.037 (0.026-0.053)
	CT	1.031 (0.853-1.246)	18.15 (13.99-23.54)	0.020 (0.008-0.047)	22.97 (14.77-35.71)	5.960 (0.666-53.34)	46.55 (33.82-64.07)	8.18 (4.40-15.21)	0.058 (0.025-0.137)
	TT	-	-	-	-	-	-	-	-
	P value	0.02	0.3	0.2	0.9	0.2	0.4	0.9	0.3
MMP-13 77A/G	AA	0.522 (0.419-0.650)	15.62 (13.47-18.13)	0.030 (0.022-0.041)	23.06 (18.64-28.54)	2.337 (1.380-3.957)	53.30 (47.05-60.38)	8.54 (7.21-10.12)	0.050 (0.036-0.069)
	AG	0.683 (0.458-1.017)	14.37 (11.10-18.59)	0.037 (0.019-0.071)	22.96 (16.01-32.93)	2.685 (1.215-5.931)	48.10 (39.30-58.88)	8.07 (6.09-10.68)	0.031 (0.016-0.058)
	GG	-	-	-	-	-	-	-	-
	P value	0.22	0.6	0.6	0.98	0.8	0.4	0.7	0.14
TNF-α 308 G/A	AA	0.730 (0.325-1.639)	21.40 (14.72-31.13)	0.039 (0.010-0.156)	17.42 (8.16-37.21)	0.804 (0.369-1.755)	57.25 (37.28-87.92)	13.14 (8.72-19.80)	0.111 (0.054-0.227)
	AG	0.558 (0.429-0.727)	14.65 (11.96-17.95)	0.031 (0.020-0.050)	23.41 (17.78-30.83)	4.460 (2.097-9.486)	51.62 (43.92-60.66)	8.39 (6.71-10.48)	0.043 (0.028-0.064)
	GG	0.453 (0.281-0.732)	16.54 (13.36-20.47)	0.027 (0.018-0.040)	23.62 (17.25-32.34)	1.998 (0.879-4.542)	46.63 (39.84-54.59)	7.04 (5.36-9.26)	0.023 (0.012-0.045)
	P value	0.4	0.24	0.8	0.7	0.065	0.6	0.1	0.02
CCR5-Δ32	wt/wt	0.601 (0.484-0.747)	15.75 (13.71-18.09)	0.031 (0.022-0.043)	21.55 (17.50-26.53)	2.441 (1.482-4.020)	50.72 (44.83-57.38)	8.10 (6.95-9.45)	0.041 (0.029-0.057)
	wt/Δ32	0.431 (0.286-0.652)	13.64 (9.87-18.85))	0.032 (0.020-0.051)	27.15 (18.55-39.73)	2.662 (1.222-5.801)	52.01 (42.66-63.42)	9.44 (6.49-13.72)	0.043 (0.021-0.088)
	Δ32/Δ32	-	-	-	-	-	-	-	-
	P value	0.15	0.4	0.9	0.3	0.9	0.9	0.4	0.9

SNP: Single nucleotide polymorphisms; MMP: Matrix metalloprotease. Values are expressed as mean (95%CI) in ng/mL. APRI: AST to Platelet Ratio Index; FIB-4: Fibrosis-4 index; TIMP: Tissue inhibitor of metalloprotease.