Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients

doi:10.5501/wjv.v6.i2.36

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World Journal of Virology

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World J Virol. May 12, 2017; 6(2): 36-45
Published online May 12, 2017. doi: 10.5501/wjv.v6.i2.36

Table 2 Genotypic frequencies of different single nucleotide polymorphisms according to liver fibrosis ≥ F2 and hepatitis C virus status

SNP	Genotype	No fibrosis n (%)	Fibrosis n (%)	P value	HIV mono-infected n (%)	HIV/HCV coinfected n (%)	P value
MMP-1 -1607 1G/2G	1G1G	14 (20.3)	4 (16.7)	0.9	9 (16.1)	9 (24.3)	0.6
	1G2G	13 (18.8)	5 (20.8)		12 (21.4)	6 (16.2)
	2G2G	42 (60.9)	15 (62.5)		35 (62.5)	22 (59.5)
MMP-8 -799C/T	CC	30 (27.0)	6 (22.2)	0.6	25 (26.3)	11 (25.5)	1
	CT	47 (42.4)	10 (37.0)		39 (41.1)	18 (41.9)
	TT	34 (30.6)	11 (40.8)		31 (32.6)	14 (32.6)
MMP-9 -1562 C/T	CC	78 (81.2)	28 (84.8)	0.6	61 (83.6)	45 (80.4)	0.6
	CT	18 (18.8)	5 (15.2)		12 (16.4)	11 (19.6)
	TT	0 (0.0)	0 (0.0)		0 (0.0)	0 (0.0)
MMP-13 -77A/G	AA	89 (74.8)	21 (61.8)	0.14	70 (72.9)	40 (70.2)	0.7
	AG	30 (25.2)	13 (38.2)		26 (27.1)	17 (29.8)
	GG	0 (0.0)	0 (0.0)		0 (0.0)	0 (0.0)
TNF-α -308 G/A	AA	11 (11.3)	4 (11.8)	0.5	7 (9.5)	8 (14.0)	0.7
	AG	62 (63.9)	18 (52.9)		46 (62.1)	34 (59.6)
	GG	24 (24.7)	12 (35.3)		21 (28.4)	15 (26.3)
CCR5-Δ32	wt/wt	96 (80.0)	30 (88.2)	0.27	77 (79.4)	49 (86.0)	0.3
	wt/Δ32	24 (20.0)	4 (11.8)		20 (20.6)	8 (14.0)
	Δ32/Δ32	0 (0.0)	0 (0.0)		0 (0.0)	0 (0.0)

SNP: Single nucleotide polymorphisms; HCV: Hepatitis C virus; HIV: Human immunodeficiency virus; MMP: Matrix metalloprotease.

Citation: Collazos J, Valle-Garay E, Suárez-Zarracina T, Montes AH, Cartón JA, Asensi V. Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients. World J Virol 2017; 6(2): 36-45
URL: https://www.wjgnet.com/2220-3249/full/v6/i2/36.htm
DOI: https://dx.doi.org/10.5501/wjv.v6.i2.36