Role of RNA secondary structure in emergence of compartment specific hepatitis B virus immune escape variants

Table 2 Comparison of the thermodynamic characteristics of the minimum free energy secondary structure predictions for subgenotypes A1 and A2 pgRNA

Features	Subgenotype A1	Subgenotype A2
Minimum free energy of the optimal secondary structure	-1052.10 kcal/mol	-1049.50 kcal/mol
Free energy of the thermodynamic ensemble	-1099.56 kcal/mol	-1098.93 kcal/mol
Minimum free energy of the centroid secondary structure	-722.20 kcal/mol	-679.21 kcal/mol
Ensemble diversity	863.25	954.99