Neuropathology of JC virus infection in progressive multifocal leukoencephalopathy in remission

Figure 2 Histopathology of the original diagnostic biopsy. A: Histopathology of the cerebellar biopsy specimen from 1999 stained with hematoxilin and eosin. Atypical glia is indicated by arrows. Inset shows higher magnification of one example. Numerous macrophages surround the atypical cells and fill the parenchyma; B: Immunohistochemical staining for SV40 T antigen of another section from the biopsy shows numerous scattered strongly positive brown stain in nuclei of atypical glial cells, consistent with oligodendroglial infection by JC virus. Inset shows a higher magnification of another example of a positive glial cell; C: Immunohistochemistry for p53 detected strongly positive atypical glia and scattered weaker staining of macrophages consistent with inflammatory reaction to viral infection (A-C).