Hepatitis E virus infection: Epidemiology and treatment implications

Table 2 Recent evidences on the outcome of therapies against acute hepatitis E infection

Ref.	Type of study	Patient profile	HEV genotype	Ribavirin regimen	Results
Gerolami et al[84]	Case report	61-year-old man, 7 d after admission ALT 4565 IU/L	3	1200 mg/d for 21 d	At day 21 of treatment, ALT normalized, RNA almost undetectable
Péron et al[88]	Case report	79-year-old man with chronic liver disease, acute kidney failure	3f	200 mg/d for 3 mo	Serum HEV RNA negative at 1 mo therapy, stopped dialysis at 2 mo
		A patient with chronic liver disease	3f	1000 mg/d for 10 d	Viral load 4.07 log copies/mL declined to 2.54 log copies/mL at day 6, Hgb 12.6 g/dL declined to 11.6 g/dL at day 6 of treatment
Del Bello et al[95]	Case report	65-year-old man, liver transplant recipient Guillain-Barré syndrome with severe necrotizing myositis	3f	400 mg/d adapted to GFR (40 mL/min) for 3 mo	HEV RNA undetectable by day 15, progressive recovery of mobility
Pischke et al[96]	Case from prospective case series	42-year-old woman had traveled to Eritrea and acquired severe acute hepatitis E	1e	For 6 wk (dose: Undefined)	Rapidly improved liver function and cleared HEV
Robbins et al[97]	Case report	39-year-old man HIV (+) CD4 51/mm3 prothrombin index 45%	3c	1200 mg/d (15 mg/kg per day) for 12 wk	Gradual normalization of LFT-HEV RNA decreased to < 100 copies/mL at 1 mo of treatment
Riveiro-Barciela et al[98]	Case report	68-year-old man with Waldenström's macroglobulinemia	3f	800 mg/d for 12 wk	Achieved SVR after 12 wk; no ribavirin-related side effect reported

LFT: Liver function test; ALT: Alanine transaminase; Hgb: Haemoglobin; GFR: Glomerular filtration rate; SVR: Sustained virological response; HIV: Human immunodeficiency virus; HEV: Hepatitis E virus.