Purinergic signaling and human immunodeficiency virus/acquired immune deficiency syndrome: From viral entry to therapy

Figure 3 Schematic representation of purinergic receptors involvement in human immunodeficiency virus infection. Pannexin hemichannels (Panx-1) are open in response to ATP release and activation of purinergic receptors, facilitating viral entry, fusion and replication. The blockage of viral entry by P2X1 antagonists suggests it is involved in this stage of infection. P2Y2 increases cell membrane depolarization facilitating fusion. P2X7 and P2Y1 are involved in later steps of viral cycle.