Purinergic signaling and human immunodeficiency virus/acquired immune deficiency syndrome: From viral entry to therapy

Table 1 Purinergic receptors families, subfamilies and subtypes, subdivisions

Family	Subfamily	Subtype	Ligand	Cell type expression
P1	A1	NA	Adenosine	Neutrophils, monocytes, macrophages, and DCs
	A2A	NA	Adenosine	Neutrophils, monocytes, macrophages, DCs, T, B and NK cells
	A2B	NA	Adenosine	Neutrophils, monocytes, macrophages, DCs, T and NK cells
	A3	NA	Adenosine	Neutrophils, monocytes, macrophages, DCs, T and NK cells
P2	P2Y	P2Y1	ADP	Neutrophils, monocytes, macrophages, DCs, T, B and NK cells
		P2Y2	ATP, UTP	Neutrophils, monocytes, macrophages, DCs, T, B and NK cells
		P2Y4	UTP (ATP, UDP)	Monocytes, macrophages, DCs, T and B cells
		P2Y6	UDP, UTP	Neutrophils, monocytes, macrophages, DCs, T and B cells
		P2Y11P2Y8	ATP	Monocytes, macrophages, DCs, T and B cells
		P2Y12	ADP	Neutrophils, monocytes, macrophages, T and B cells
		P2Y13	ADP, ATP	Neutrophils, monocytes, DCs, T and B cells
		P2Y14	UDP, glucose	Neutrophils, DCs, T, B and NK cells
	P2X	P2X1	ATP	Neutrophils, monocytes, macrophages, DCs, T, B and NK cells
		P2X2	ATP	B cells
		P2X3	ATP	B and NK cells
		P2X4	ATP	Neutrophils, monocytes, macrophages, DCs, T, B and NK cells
		P2X5	ATP	Neutrophils, monocytes, macrophages, DCs, T and B cells
		P2X6	ATP	B and NK cells
		P2X7	ATP	Neutrophils, monocytes, macrophages, DCs, T, B and NK cells

NA: Not applicable; DC: Dendritic cells; NK: Natural killer cells. Adapted from Junger WC, 2011[56].