Pharmacogenetics as a tool to tailor antiretroviral therapy: A review

doi:10.5501/wjv.v4.i3.198

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Aug 12, 2015 (publication date) through Dec 27, 2024

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World Journal of Virology

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2220-3249

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Virology. Aug 12, 2015; 4(3): 198-208
Published online Aug 12, 2015. doi: 10.5501/wjv.v4.i3.198

Table 2 Pharmacogenetics and highly active antiretroviral therapy response

Polymorphisms	Drug response
CYP3A5*1	Increased PIs clearance
CYP2B6 rs3475274, rs28399499	Increased EFV and NVP plasma concentrations
ABCB1 3435C > T	Better viral responses to EFV exposure
ABCB1 rs1045642 (3435T > C)	CT/CC genotype associated with higher CD4 count in EFV, 3TC, NVP containing regimen

PIs: Protease inhibitors; NVP: Nevirapine; EFV: Efavirenz.

Citation: Aceti A, Gianserra L, Lambiase L, Pennica A, Teti E. Pharmacogenetics as a tool to tailor antiretroviral therapy: A review. World J Virology 2015; 4(3): 198-208
URL: https://www.wjgnet.com/2220-3249/full/v4/i3/198.htm
DOI: https://dx.doi.org/10.5501/wjv.v4.i3.198