Evolution of an avian H5N1 influenza A virus escape mutant

Table 2 Comparison of amino acid signatures in selected genes of avian and human strains to Egyptian H5N1 strains

Gene	Residue	Avian1	Human	Egyptian H5N1	A/CK/Egypt/F10/2009
PB2	475	L214M1	M839L3	L52M2	L
	588	A203/T6/V6	I835/V3/A2	A53/T1	A
	613	V212/A3	T816/I16/A8/V1	V54	V
	627	E196/K19	K838/R2/E1	K48/E6	K
	674	A204/S6/T2/G2/E1	T836/A2/I2/P1	A54	A
PB1	327	R147/K3	K766/R66	R58	R
	336	V142/I8	I773/V59	V58	V
PA	225	S213C1	C829S10	S	S
	268	L214	I827K11	L	L
	356	K212X1R1	R827K11	K	K
	382	E208D5V1	D824E11V2N1	E	E
	404	A214	S828A9P1	A	A
	409	S189N24I1	N830S7I1	S77N1	S
NP	283	L372/P1	L7/P643	L61	L
	293	R371/K2	R28/K622	R60/K1	R
	305	R369/K4	K636/R14	R61	R
	313	F371/I1/L1	Y642/F8	F61	F
	357	Q368/K4/T1	K44/R8/Q1	Q61	Q
	372	E357/D15/K1	D630/E23	E61	E
	422	R373	K630/R23	R61	R
	442	T372/A1	A629/T23/R1	T61	T
	455	D373	E630/D22/T1	D60/E1	D
M1	115	V856/I2/L1/G1	I981/V9	V88	V
	121	T840/A19/P1	A988/T2	T88	T
	137	T859/A1/P1	A974/T12	T88	T
M2	11	T434/I11/S2	I911/T44	T90	T
	20	S471/N13	N926/S29	S90	S
	57	Y481/C1/H1	H913/Y33/R2/Q1	Y90	Y
NS2	70	S453/G21/D1	G903/S2	S61	S

¹Avian and human amino acid signatures in different viral genes of influenza A viruses as previously determined[20]. Numerical superscripts refer to the number of strains that possess those residues.