Viral proteins and Src family kinases: Mechanisms of pathogenicity from a “liaison dangereuse”

Figure 2 Models of mechanisms connecting viral proteins and Src family kinases and downstream effects. Viral proteins bind to the various modular domains of Src family kinases (SFKs), with (A) or without (B-D) concurrent association with other host proteins, resulting in the subsequent phosphorylation of the viral proteins (VPs) by which they are engaged (A, B), ultimately conferring new functional properties to VPs, or of different VPs to stabilize multiprotein complexes (C); Moreover, VPs may delocalize SFKs to different cell compartments, where SFKs in the activated form can process local substrates or act as non-catalytic mediators of the action of VPs themselves (D) (see text for further details regarding how specific VPs fit into each model. Solid lines indicate binding, arrows indicate downstream event. HP: Host protein; pY: Phosphotyrosine.