Herpes simplex keratitis: A brief clinical overview

Table 1 Selected literature on herpes simplex virus occurrence in immunocompromised individuals

Ref.	Predisposing condition	Summary
Gupta et al[419]	Necrotizing fascitis	HZO was the first sign of reactivation of varicella-zoster
Murgova and Balchev[420]	COVID-19	COVID-19 vaccines caused a reactivation in HSV ocular diseases
Yildiz et al[421]	COVID-19	COVID-19 vaccines caused a reactivation in HSV ocular diseases
Huang et al[422]	COVID-19	HSK was the 3rd most common corneal complication after COVID-19 vaccination
Matharu et al[423]	Cancer	VZV and HSV cornea co-infection in a patient with systemic immunosuppression
Cohen et al[424]	COVID-19	Herpetic cornea infection may develop post SARS-CoV-2 vaccinations
Yoshida et al [425]	RA	Individuals with RA have the tendency to develop HSK which is usually more severe due to their immunocompromised state
Fei et al[426]	COVID-19	HSK could happen after vaccination with a possible preponderance
Al-Dwairi et al[427]	COVID-19	Reactivation of HSK on cornea graft after taking SARS-CoV-2 mRNA vaccine
Majtanova et al[428]	COVID-19	Five incidences of HSK after COVID-19 vaccination
Roberts et al[429]	COVID-19	Negative result of COVID-19 in the tears in a patient with recurring HSV Keratitis
Kuziez et al[430]	COVID-19	HSK was reviewed as an adverse effect occurring after COVID-19
Mohammadzadeh et al[431]	COVID-19	HSK-suspected reactivation resulted in corneal graft rejection
Ichhpujani et al[432]	COVID-19	HSK was implicated in a review of associated complications reported after vaccination
Ono et al[433]	Human herpes virus	Reactivation of HHV-6B infection
Sinha et al[434]	Psoriasis	HSV keratitis after taking secukinumab for the treatment of psoriasis

COVID-19: Coronavirus disease 2019; HSV: Herpes simplex virus; HSK: Herpes simplex keratitis; SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2; RA: Rheumatoid arthritis; HZO: Herpes zoster ophthalmicus; VZV: Varicella zoster virus; HHV-6B: Human herpes virus 6B.