Basic Study
Copyright ©The Author(s) 2023.
World J Virol. Dec 25, 2023; 12(5): 296-308
Published online Dec 25, 2023. doi: 10.5501/wjv.v12.i5.296
Table 1 Demographic, clinical, and laboratory characteristics of HBsAg-positive patients with high and low viral load using 104 copies per mL as the cutoff point, n (%)
FactorsALL
High HBV DNA
Low HBV DNA
P value
Case n = 1603
Case n = 815
Case n = 788
Demographic
Age (yr)52 (43–60)51 (40–60)53 (45–61)0.010
Male gender1015 (63.28)131 (69.6)401 (68.2)0.703
Laboratory tests
FBG (mmol/L)5.10 (4.61–5.87)5.00 (4.5–5.7)5.21 (4.77–6.00)< 0.001
ALT (U/L)47.95 (25.00–109.92)68.3 (37.1–155.83)31.7 (20.3–67.7)< 0.001
AST (U/L)41.19 (25.00–81.97)52.95 (33.33–106.8)29.86 (21.31–55.55)< 0.001
ALP (U/L)81.40 (63.63–109.00)85.30 (66.00–116.60)76.65 (61.9–104.00)0.003
γ-GGT (U/L)51.20 (22.89–113.36)60.00 (29.13–135.00)41.60 (18.97–100.12)0.038
LDH (U/L)194.8 (170.23–231.10)196.00 (171.56–239.00)194.00 (168.94–224.61)0.006
Albumin (g/L)40.70 (35.33–44.70)39.60 (33.02–43.51)41.96 (37.49–45.80)0.045
Total bilirubin (µmol/L)16.53 (11.63–25.24)17.60 (12.20–27.70)15.39 (11.37–23.20)0.165
Bile acids (µg/mL)11.00 (5.18–30.00)14.30 (6.30–34.20)8.70 (4.26–23.88)0.002
Total cholesterol (mmol/L)4.25 (3.55–5.01)4.19 (3.50–4.92)4.37 (3.61–5.10)0.517
Triglycerides (mmol/L)1.06 (0.73–1.53)1.02 (0.73–1.44)1.12 (0.74–1.71)< 0.001
HDL-C (mmol/L)1.15 (0.90–1.41)1.19 (0.91–1.43)1.12 (0.89–1.38)0.029
LDL-C (mmol/L)2.40 (1.87–2.98)2.27 (1.76–2.89)2.51 (1.95–3.10)0.018
apoA (g/L)1.19 (1.01–1.38)1.14 (0.99–1.27)1.18 (1.02–1.39)0.849
apoB (g/L)0.87 (0.70–1.06)0.84 (0.69–1.01)0.91 (0.73–1.10)0.002
Steatosis163 (10.2)25 (3.1)138 (17.5)< 0.001
HBeAg sero-positive661 (41.2)460(56.4)201 (25.5)< 0.001
HBV: Chronic hepatitis B virus; FBG: Fasting blood glucose; ALT: Alanine Aminotransferase; AST: Aspartateaminotransferase; ALP: Alkaline Posphatase; LDH: lactic dehydrogenase; HDL: High density lipoprotein; LDL: Low- density lipoprotein; apo-A: Apolipoprotein-A; apo-B: Apolipoprotein-B.