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©The Author(s) 2023.
World J Virol. Jan 25, 2023; 12(1): 30-43
Published online Jan 25, 2023. doi: 10.5501/wjv.v12.i1.30
Published online Jan 25, 2023. doi: 10.5501/wjv.v12.i1.30
Table 5 Studies evaluating outcomes and predictors in autoimmune hepatitis with coronavirus disease 2019
Ref. | Study | Patients | Results | Predictors of outcomes |
Efe et al[47] | Multicentre retrospective study from 34 centres in Europe and the Americas | 110 AIH patients | Acute liver injury: 37.1% | Predictor of severe COVID-19: cirrhosis (OR: 17.46); Immunosuppression not associated with severe COVID-19 (OR: 0.26) |
Di Giorgio et al[46] | Phone based survey in tertiary centre | adult AIH patients: AIH (n = 97, 96%); PSC/AIH overlap (n = 2, 2%); PBC/AIH (n = 2, 2%); 4 patients had confirmed COVID | Severe COVID: 1; Death: 1 | No difference in risk factors of mortality |
Marjot et al[49] | Retrospective data from three international registries | 70 AIH cases among 932 patients with CLD with COVID-19 | No differences between AIH and non-AIH related CLD in Hospitalization (76% vs 85%); ICU admission (29% vs 23%); Death (23% vs 20%) | Factors predicting mortality in AIH: Age (OR: 2.16/10 yr); Child-Pugh class [B (OR: 42.48) and C (OR: 69.30)] cirrhosis |
Efe et al[50] | Retrospective data from 15 countries | 254 AIH patients | Hospitalization: 94 (37%); Death: 18 (7.1%) | Factors associated with COVID-19 severity: Systemic glucocorticoids (aOR: 4.73); Thiopurines (aOR: 4.78); Mycophenolate mofetil (aOR: 3.56); Tacrolimus (aOR: 4.09) |
- Citation: Walia D, Saraya A, Gunjan D. COVID-19 in patients with pre-existing chronic liver disease – predictors of outcomes. World J Virol 2023; 12(1): 30-43
- URL: https://www.wjgnet.com/2220-3249/full/v12/i1/30.htm
- DOI: https://dx.doi.org/10.5501/wjv.v12.i1.30