Monkeypox: An emerging zoonotic pathogen

Figure 1 Cycle of monkeypox virus. When the virion binds and fuses with the host cell membrane, the viral core is released in the cytoplasm. Enzymes, and then factors, initiate transcription. Most virions remain in the cytoplasm. Virus- and host-encoded proteins concerning cell surface-associated enveloped virions and cell surface-associated enveloped virions guard them to complement activation. IMV: Intracellular reduced virion; EEV: Extracellular enveloped virion; CEV: Cell surface-associated enveloped virion; IEV: Intracellular enveloped virion.