Role of high dose vitamin C in management of hospitalised COVID-19 patients: A minireview

Table 2 Meta-analyses evaluating the role of Vitamin C in COVID-19

S. No.	Title	Year of publication	Country of origin	Included studies	Included sample size	Results in brief
1	Intravenous vitamin C use and risk of severity and mortality in COVID-19: A systematic review and meta-analysis[45]	2022	China	7 studies (3 RCTs, 4 observational studies)	807 patients	IV vitamin C treatment did not affect disease severity or mortality
2	The effectiveness of high-dose intravenous vitamin C for patients withcoronavirus disease 2019: A systematic review and meta-analysis[46]	2022	Korea	5 studies (3 RCTs, 2 retrospective trials)	374 patients (186 HDIVC and 184 control group)	No difference in hospital LOS or mortality
3	Vitamin C and COVID-19 treatment: A systematic review and metaanalysis of randomized controlled trials[47]	2021	India	6 RCTs	572 patients	Vitamin C treatment didn’t reducemortality, ICU LOS, hospital LOS or need for invasive mechanical ventilation

RCT: Randomised control trial; IV: Intravenously; HDIVC: High dose intravenous vitamin C; LOS: Length of stay; ICU: Intensive care unit.