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World J Virol. Jul 25, 2022; 11(4): 176-185
Published online Jul 25, 2022. doi: 10.5501/wjv.v11.i4.176
Table 1 Risk factors for air leaks in coronavirus disease 2019
Risk factors
Probable mechanism
Comorbidities like hypertension, diabetes mellitus, and morbid obesity By increasing the risk of diffuse alveolar damage
Persistent cough Significant strain by causing sudden alveolar distension
Time from symptom onset Increased risk of P-SILI
Mode of ventilation
Non-invasive: HFNC and NIVIncreasing the risk of P-SILI
Invasive mechanical ventilationVentilation associated lung injury
CorticosteroidsWeakening the interstitial tissue, lowering immunity, and impairing healing