Molecular and clinical aspects of hepatitis D virus infections

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Jun 12, 2012 (publication date) through Jul 22, 2024

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World Journal of Virology

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2220-3249

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Virol. Jun 12, 2012; 1(3): 71-78
Published online Jun 12, 2012. doi: 10.5501/wjv.v1.i3.71

Table 1 Molecular interactions between hepatitis B virus and hepatitis D virus

HBV polymerase mutation(s)	Corresponding HBsAg mutation(s)	Clinical relevance	Effect(s) on HDV
rtM204V	sI195M(A)	LMV resistance	Enhanced HDV secretion
rtM204I	sW196L/S/stop	LMV resistance	S, L: no HDV secretion
rtD205H	sW196F	Selected during LMV treatment with reduced binding to anti-HBsAg antibodies	Reduced HDV secretion
rtV173L	sE164D	Selected during LMV treatment with reduced binding to anti-HBsAg antibodies	Reduced HDV secretion
rtV173L/rtM204V	sE164D/sI195M	Selected during LMV treatment with reduced binding to anti-HBsAg antibodies	Support HDV secretion

LMV: Lamivudine; HDV: hepatitis D virus; HBV hepatitis B virus; HBsAg: HBV surface antigen.

Citation: Dastgerdi ES, Herbers U, Tacke F. Molecular and clinical aspects of hepatitis D virus infections. World J Virol 2012; 1(3): 71-78
URL: https://www.wjgnet.com/2220-3249/full/v1/i3/71.htm
DOI: https://dx.doi.org/10.5501/wjv.v1.i3.71