Delivery strategies for novel vaccine formulations

Figure 1 Selective targeting of antigens to dendritic cells. Schematic diagram of the new bacteriophage vector displaying at the N-terminus of the pIIIgene a single chain antibody fragment (scFv) binding the mouse dendritic cells DEC-205 receptor and an antigenic peptide as N-terminal fusion to the major coat pVIII protein. The scFv is composed of heavy (VH) and light (VL) chain variable regions of the mouse monoclonal antibody NLDC-145, assembled with a (Gly4Sert)3 linker to yield a 750 bp long single-chain fragment. g: Gene; p: Protein.