Serological diagnosis of Epstein-Barr virus infection: Problems and solutions

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Feb 12, 2012 (publication date) through Dec 29, 2024

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World Journal of Virology

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2220-3249

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Virol . Feb 12, 2012; 1(1): 31-43
Published online Feb 12, 2012. doi: 10.5501/wjv.v1.i1.31

Table 5 Additional tests in the case of an isolated viral capsid antigen IgG pattern

Tests	Advantages	Disadvantages
EBV IgG immunoblotting	Useful in distinguishing acute from past infection	Individual antibody production; expensive
IgG avidity	Useful in distinguishing acute from past infection	Individual maturation. Not useful in newborns
Molecular biology	Useful in distinguishing acute from past infection	Uncorrected conservation of blood sample, presence of nucleasis; expensive; organisational problems
Heterophile antibodies	Useful in distinguishing acute from past infection if positive; inexpensive and simple	Not very sensitive (especially in children)
Anti-EA(D) IgG	Of some use in distinguishing acute from past infection; costs the same as a screening test	Not useful in at least 10% of cases

EBV: Epstein-Barr virus.

Citation: De Paschale M, Clerici P. Serological diagnosis of Epstein-Barr virus infection: Problems and solutions. World J Virol 2012; 1(1): 31-43
URL: https://www.wjgnet.com/2220-3249/full/v1/i1/31.htm
DOI: https://dx.doi.org/10.5501/wjv.v1.i1.31