Porcine reproductive and respiratory syndrome virus vaccines: Immunogenicity, efficacy and safety aspects

Table 1 Porcine reproductive and respiratory syndrome virus genome and relevant information

ORF	Product	Function	Role in immunity/protection	Ref.
1a	Nsp1α	Papain-like cysteine protease	Potential IFN and TNFα antagonist	[66-68]
	Nsp1β	Papain-like cysteine protease	Potential IFN and TNFα antagonist	[66,68,69]
	Nsp2	Cysteine protease	Potential IFN antagonist	[70]
	Nsp3	Transmembrane protein	NA	[70]
	Nsp4	Serine protease	NA	[70]
	Nsp5	Transmembrane protein	NA	[70]
	Nsp6	NA	NA	[70]
	Nsp7α	NA	Potential antigen for serological determination of persistence infection	[70]
	Nsp7β	NA	Potential antigen for serological determination of persistence infection	[70]
	Nsp8	NA	NA	[70]
1b	Nsp9	RNA-dependent RNA polymerase	NA	[70]
	Nsp10	Helicase	NA	[70]
	Nsp11	Endoribonuclease	Potential IFN antagonist	[70,71]
	Nsp12	NA	NA	[70]
2a	GP2	Minor envelope protein; interacts with CD163	Minor neutralizing epitope	[72]
2b	E protein	Minor envelope protein; possibly form oligomeric ion channel	NA	[72]
3	GP3	Minor envelope protein	Minor neutralizing epitope	[72]
4	GP4	Minor envelope protein; interacts with CD163	Minor neutralizing epitope	[72]
5	GP5	Major envelope protein; interacts with sialoadhesin	Major neutralizing epitope	[72]
6	M protein	Major envelope protein; interacts with heparan sulfate	T cell epitope; minor neutralizing epitope	[72]
7	N protein	Nucleocapsid	Non-neutralizing epitope	[72]

Nsp: Non-structural protein; GP: Glycoprotein; NA: No data available; ORF: Open-reading frames.