Impact of recipient functional status on 1-year liver transplant outcomes

Table 3 Pre-transplant clinical characteristics by pre-transplant functional status, Scientific Registry of Transplant Recipients 2005-2014 (n = 38278)

Characteristica	Functional impairment/disability
	A: None (n = 11674)	B: Moderate (n = 17530)	C: Severe (n = 9074)
Waitlist time, mo	4.0 (1.3-10.2)	3.7 (1.1-10.3)	2.1 (0.4-8.4)
Weight loss ≥ 5%b	19.7	24.2	27.0
BMI, kg/m2
Underweight (< 18.5)	1.6	1.6	2.4
Normal (18.5-25)	28.3	27.5	27.1
Overweight (25-30)	37.0	36.0	34.0
Obese (≥ 30)	33.2	35.0	36.5
MELD
< 15	49.9	34.9	14.3
15-29	45.9	56.5	45.9
≥ 30	4.2	8.6	39.8
Total bilirubin	2.3 (1.2-4.4)	3.0 (1.6-6.1)	6.6 (2.9-17.2)
International normalized ratio	1.4 (1.2-1.7)	1.5 (1.3-1.9)	2.0 (1.5-2.6)
Serum creatinine	0.9 (0.7-1.2)	1.0 (0.8-1.3)	1.4 (0.9-2.3)
Serum sodium	137 (134-140)	136 (133-139)	135 (132-139)
Child Pugh score
A (Good)	23.8	11.8	4.1
B (Fair)	38.7	33.8	18.5
C (Poor)	37.5	54.4	77.4
Ascitesc
None	36.9	23.0	14.0
Mild/Moderate	48.4	52.4	43.5
Severe	14.8	24.6	42.6
Encephalopathyd
None	52.7	36.6	26.0
Grade 1-2	44.4	57.5	61.4
Grade 3-4	2.9	5.9	12.6
Albumin
> 3.5	26.7	19.3	22.8
2.8-3.5	41.7	41.2	39.0
< 2.8	31.6	39.6	38.2
Dialysise	0.9	1.6	10.9
Portal Vein Thrombosis	6.5	9.7	12.4

^aColumn percentage or median (interquartile range);

^bRelative to weight at time of waitlist registration;

^cMild/Moderate ascites: Diuretic-responsive; Severe ascites: Diuretic-refractory;

^dEncephalopathy grade 1-2 (or precipitant-induced); Grade 3-4 (or chronic);

^eDialyzed at least twice in prior week. All distributions varied significantly across categories of functional status (P < 0.001). BMI: Body mass index; MELD: Model for End-Stage Liver Disease.