Histological and clinical evaluation of marginal donor kidneys before transplantation: Which is best?

Table 5 Studies on molecular markers measured in 0-h biopsies (up to 2011)

Ref.	Pats	f/u	Findings/timing of biopsy-technology
Hoffmann et al[28], 2002	24	1 h	IRI injury ass w increased adhesion, chemotaxis, apoptosis, monocyte recruitment/activation transcripts.Post-reperfusion/RT-PCR
Hauser et al[29],2004	36	1	Increased Communication, apoptosis, inflammation
Kainzet al[30],2004	10	1	DD kidneys distinctly different transcripts in the TI but not in the G compartment compared to LD. End of CIT/microarrays
Avihingsanon et al[31],2005	75	6	15 selected genes associated with outcomes, included DGF, REJ and 6 mofunction. Post-reperfusion/RT-PCR
Kainzet al[32],2007	31	12	Increased immunity, signal transduction, oxidative stress response associated with lower 1-year function
Park et al[33],2007	15	12	Increased inflammation and immune response at 1-year in uncomplicated grafts
Mas et al[34],2008	33	3	Increased immunity, inflammation and apoptosis genes associated with DGF. End of CIT/microarrays
Mueller et al[35],2008	87	12	Increased acute phase, complement, chemochines and reduced metabolism, transporters in DD versus LD, transcriptome identifies risk for DGF better than clinical ± histological markers. Post-reperfusion/ microarrays
Perco et al[36], 2009	82	12	Increasedimmunity/defense, communication, apoptosis in damaged kidneys, CADI score + clinic explained 14%, 3 biomarkers 28% of 1-year creatinine variability. End of CIT/ microarrays
Naesens et al[37], 2009	28	36	Complement genes differ between LD and DD and are associated with early and late function. End of CIT and post-transplant/ microarrays
Bodonyi-Kovacs et al[38], 2010	75	48	Pre-selected genes associated with 2-year graft function. Post-reperfusion/ RT-PCR
Cravedi et al[39], 2010	49	12	LDvs DD differ by inflammation, donor age and ITGB2 prognostic for 1-year function. Post-reperfusion/RT-PCR

f/u:Follow up in months; IRI:Ischemia-reperfusion injury; DD:Deceased donor; LD:Living donor; IGF:Immediate graft function; DGF:Delayed graft function; REJ:Rejection; CIT: Cold ischemia time; TI:Tubulointerstitial; G:Glomerular.