Complement-mediated renal diseases after kidney transplantation - current diagnostic and therapeutic options in de novo and recurrent diseases

Table 2 Morphological features in microangiopathy

Active lesions	Chronic lesions
Glomeruli: Thrombi - Endothelial swelling or denudation - Fragmented RBCs - Subendothelial flocculent material. EM: Mesangiolysis - Microaneurysms	Glomeruli: LM: Double contours of peripheral capillary walls, with variable mesangial interposition - EM: New subendothelial basement membrane - Widening of the subendothelial zone
Arterioles: Thrombi - Endothelial swelling or denudation - Intramural fibrin - Fragmented red blood cells - Intimal swelling - Myocyte necrosis	Arterioles: Hyaline deposits
Arteries: Thrombi - Myxoid intimal swelling - Intramural fibrin - Fragmented red blood cells	Arteries: Fibrous intimal thickening with concentric lamination (onion skin)

Adapted from Goodship et al[12]. EM: Electron microscopy; LM: Light microscopy.