Hepatitis C and renal transplantation in era of new antiviral agents

Table 1 The four classes of direct acting antivirals agents

The four classes of DAAs	Mechanism of action	Drugs (targeted genotypes in brackets)
NS3/4A PIs (PIs)	Block a viral enzyme (protease) that enables the HCV to survive and replicate in host cells	Glecaprevir (1-6) Paritaprevir (1, 4) Voxilaprevir (1-6) Grazoprevir (1, 3, 4)
Nucleoside and nucleotide NS5B polymerase inhibitors	Target the HCV to stop it from making copies of itself in the liver. So doing block the virus from multiplying	Sofosbuvir (1-4)
NS5A inhibitors	Block a virus protein, NS5A, that HCV needs to reproduce and for various stages of infection	Ombitasvir (1, 4) Pibrentasvir (1-6) Daclatasvir (3) Elbasvir (1, 4) Ledipasvir (1) Ombitasvir (1) Velpatasvir (1-6)
Non-nucleoside NS5B polymerase inhibitors	Stop HCV from reproducing by inserting themselves into the virus so that other pieces of the HCV cannot attach to it	Dasabuvir (1)

PIs: Protease inhibitors; HCV: Hepatitis C virus.