In vitro intracellular IFNγ, IL-17 and IL-10 producing T cells correlates with the occurrence of post-transplant opportunistic infection in liver and kidney recipients

Table 4 Univariate and multivariate Cox regression model for overall opportunistic infection between 1st and 6th month post-transplantation

Predictive factors for OI	Univariate analysis			Multivariate analysis
	HR	95%CI	P-value	HR	95%CI	P-value
Liver transplant (n = 30)
% CD8+CD69+IFNγ+ T lymphocytes	22.56	3.01-169.56	0.002	21.12	2.80-159.31	0.003
% CD4+CD69+IL-10+ T lymphocytes	3.77	1.46-9.75	0.006	2.84	1.09-7.35	0.032
% CD4+CD69+IL-17+ T lymphocytes	2.43	0.93-6.35	0.07	1.37	0.45-4.16	0.584
Total leukocyte	1.08	0.98-1.18	0.111	0.95	0.78-1.17	0.666
Total lymphocytes (%)	0.94	0.90-0.99	0.022	0.94	0.89-0.99	0.023
Total lymphocyte (cells/mm3)	1.24	1.18-1.30	0.150	1.00	0.99-1.04	0.261
Donor age	0.98	0.96-1.01	0.221	0.96	0.93-0.99	0.026
Recipient gender	2.40	0.94-6.09	0.067	4.56	1.46-14.20	0.009
TRL dose (mg/d)	0.96	0.87-1.10	0.815	0.82	0.59-1.13	0.230
MMF dose (mg/d)	0.87	0.49-1.52	0.619	0.99	0.99-1.01	0.454
Induction therapy	0.92	0.33-2.51	0.864	3.90	3.71-4.09	0.990
Post-transplant IS	1.89	0.78-4.59	0.157	1.98	0.64-6.15	0.238
Acute rejection	1.51	0.63-3.62	0.362	3.95	0.75-20.93	0.107
SALP (U/L)	1.02	0.92-1.17	0.078	1.00	0.99-1.05	0.706
SGGT (U/L)	1.19	1.13-1.25	0.035	1.01	0.91-1.03	0.333
Kindey transplant (n = 31)
% CD4+CD69+IFNγ+ T lymphocytes	2.36	1.28-4.33	0.006	3.29	1.71-6.35	< 0.001
% CD4+CD69+IL-10+ T lymphocytes	3.49	1.68-7.30	0.001	4.76	2.05-11.08	0.003
% CD8+CD69+IL-10+ T lymphocytes	4.17	1.49-11.68	0.007	2.52	0.74-8.57	0.139
Recipient gender	1.91	1.01-3.61	0.046	1.15	0.57-2.32	0.705
TRL dose (mg/d)	0.95	0.89-1.01	0.112	0.92	0.85-0.99	0.037
MMF dose (mg/d)	1.18	1.12-1.24	0.035	1.01	1.00-1.03	0.053
Induction therapy	1.32	0.91-1.91	0.143	1.50	0.96-2.35	0.076
Post-transplant IS	0.94	0.67-1.32	0.723	0.63	0.19-2.01	0.434
Acute rejection	1.34	0.64-2.81	0.439	1.44	0.59-3.48	0.417
Serum creatinine	1.02	1.00-1.03	0.014	1.02	1.00-1.04	0.013
SALP (U/L)	0.98	0.97-0.99	0.016	0.98	0.97-1.01	0.074
SGOT (U/L)	0.98	0.95-1.01	0.242	0.98	0.96-1.01	0.195

IS: Post-transplant immunosuppressive therapy; HR: Hazard ratio.