In vitro intracellular IFNγ, IL-17 and IL-10 producing T cells correlates with the occurrence of post-transplant opportunistic infection in liver and kidney recipients

Table 3 Post-transplant cut-off, area under curve, sensitivity and specificity values for the intracellular cytokine production capacity in liver transplant recipients and kidney transplant recipients as surrogate predictive biomarkers of post-transplant opportunistic infection

Biomarker	Cut-off	AUC (95%CI)	Sensitivity (95%CI)	Specificity (95%CI)
Liver transplant
% CD8+CD69+ IFNγ+ T Lymphocytes	14.95	0.897 (0.834-0.960)	85.71 (75.29-92.93)	88.37 (74.92-96.11)
% CD4+CD69+IL-17+ T Lymphocytes	2.19	0.840 (0.761-0.919)	80.56 (69.53-88.94)	81.25 (67.37-91.05)
% CD4+CD69+IL-10+ T Lymphocytes	9.35	0.902 (0.834-0.969)	78.12 (66.03-87.49)	94.87 (82.68-99.37)
Kidney transplant
% CD4+CD69+ IFNγ+ T Lymphocytes	13.83	0.750 (0.657-0.843)	72.37 (60.91-82.01)	75 (60.40-86.36)
% CD4+CD69+IL-10+ T Lymphocytes	13.95	0.856 (0.792-0.919)	71.05 (59.51-80.89)	83.33 (69.78-2.52)
% CD8+CD69+IL-10+ T Lymphocytes	11.15	0.734 (0.638-0.831)	89.33 (80.06-95.28)	52.17 (36.95-67.11)

AUC: Area under curve.