Risk factors and clinical indicators for the development of biliary strictures post liver transplant: Significance of bilirubin

Table 4 Risk factors associated with biliary stricture formation

Characteristic	Univariate regression		Multivariate regression
	Odds ratio (95%CI)	P value	Odds ratio (95%CI)	P value
Biliary strictures (n = 45)1
Donor age > 55 yr	1.54 (0.80-3.00)	NS
Cause of death - stroke	1.88 (1.00-3.52)	0.049	1.49 (0.72-3.08)	NS
Donation after circulatory death	0.55 (0.07-4.39)	NS
Split vs whole graft	1.09 (0.43-2.79)	NS
Primary sclerosing cholangitis as primary indication for transplant	2.40 (0.82-7.07)	0.11	3.10 (1.13-8.51)	0.028
Hepatic artery thrombosis	22.93 (4.59-114.52)	< 0.001	25.23 (4.73-143.64)	< 0.001
≥ 2 prior transplants	1.44 (0.51-4.07)	NS
Day 7 total bilirubin > 55 μmol/L	2.19 (1.11-4.30)	0.024	2.54 (1.22-5.29)	0.013

¹Inclusive of anastomotic, ischemic type biliary strictures, primary sclerosing cholangitis and ischemic cholangiopathy due to hepatic artery thrombosis. NS: Not significant.