Peripheral blood stem cell mobilization in multiple myeloma: Growth factors or chemotherapy?

Table 3 Impact of chemotherapy on cell yield and morbidity

Ref.	Collection strategy	n	CD34+ yield (× 10-6 cell/kg): median (range)	Hospital days: median (range)	Infection (%)	Transfusions (%) platelet/PRBC
Desikan et al[32]	CY 6 g/m2 + G-CSF 6 μg/kg per day	22	33.4 (NR)	No difference	18	86/86
	G-CSF 16 μg/kg per day	22	5.8 (NR)		0	18/55
Alegre et al[51]	CY 4 g/m2 + GM-CSF	18	6.8 (1.8-34.8)	21 (16-34)	11	33.3/27.7
	G-CSF 10 μg/kg per day	22	4.85 (2.1-10.05)	0	0	0/0
Fitoussi et al[60]	CY 7 g/m2 + HGF	74	8.6 (0.4-166)	15 (9-34)	17.6	75.7/94.6
	CY 4 g/m2 + HGF	42	13.4 (0.7-66.8)	22 (13-55)	16.7	26.2/52.4
Jantunen et al[61]	CY 4 g/m2 + G-CSF 5-10 μg/kg per day	32	4.9 (0.8-47.4)1	9 (6-14)	NR	34/53
	CY 1.2-2 g/m2 + G-CSF 5 μg/kg per day	42	5.6 (0.9-19)1	5 (3-12)	NR	0/28
Gojo et al[65]	CY 4.5 g/m2 + G-CSF	28	21.38 (0-106.8)	8 (4-24)	25	57/NR
	CY 4.5 g/m2 + VP-16 + G-CSF	49	22.39 (0-114.71)	7 (3-68)	53	67/NR
Hamadani et al[94]	CY 3-4 g/m2 + G-CSF	55	16.6 (2-82)	4 (1-9)	NR	21.8/34.5
	CY 1.5 g/m2 + G-CSF	68	7.5 (0-18)	3 (1-5)	NR	2.9/8.8
Hiwase et al[95]	CY 3-4 g/m2 + G-CSF	26	7.71	7 (3-22)	19	No difference
	CY 1-2 2 g/m2 + G-CSF	61	5.17	6 (3-18)	5

¹1st apheresis session. PRBC: Packed red blood cells; CY: Cyclophosphamide; G-CSF: Granulocyte colony stimulating factor; NR: Not reported; HGF: Hematopoietic growth factor; VP-16: Etoposide.